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Glutaredoxins are red-ox enzymes, classified as light proteins, that use glutathione as a cofactor

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This transition from hydrophobic to hydrophilic state initially weakens the hydrophobic stabilization and subsequently the newly introduced carboxyl groups interfere with electrostatic interactions

doi: 10.3390/ijms222111673 73 Montalban-ArquesAChaparroMGisbertJPBernardoD

10.1073/pnas.95.9.4882 [DOI] [PMC free article] [PubMed] [Google Scholar] Uchida K., Kawakishi S