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In addition, the inhibition of HDAC1 and HDAC2 alleviates glomerular sclerosis, interstitial fibrosis, and doxycycline-induced podocyte damage (Inoue et al., 2019)

Concerns about potential teratogenicity (birth defects), effects on pregnancy, or safety during lactation have not been adequately studied, so use during pregnancy or breastfeeding is not recommended absent compelling indication and appropriate medical supervision

Impact of polyunsaturated fatty acids during and pregnancy and lactation: A comprehensive review

Neurotrophic factors such as ciliary neurotrophic factor (CNTF) or brain-derived neurotrophic factor (BDNF) are candidates

It also normalizes blood pressure and myocardial contractions

doi: 10.1007/s11901-018-0389-7 81