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Mechanistic evidence further supported biological plausibility

Sulfur is a key component of glutathione production

In contrast, the Matrixyl vs GHK-Cu comparison reveals that GHK-Cu does not rely on a single receptor pathway

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Pollard J, Quan S, Kang T, Koch R

Further, in a rotenone-induced PD model using SH-SY5Y cells, -viniferin upregulated SIRT3, a mitochondrial deacetylase, which promoted FOXO3 deacetylation, reduced ROS production, and preserved mitochondrial function