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Description
Versus resmetirom (the approved MASH drug) Resmetirom is mechanistically orthogonal: it acts directly in the liver via thyroid hormone receptor- to increase hepatic fat oxidation, and its approval was based on biopsy endpoints in MASH with fibrosis not on weight loss
This could result in dangerously high doses
Am J Respir Crit Care Med 2000;162:566570
Accumulation of alterations in tumor cells leads to appearance of metastatic cancer cells
Our bodies dont create it, meaning we have to receive it from diet or supplementation
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