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Trends Endocrinol Metab 20, 436443, 10.1016/j.tem.2009.05.008 (2009)

The human ACE gene expresses two distinct isoforms, the somatic ACE (sACE) and testicular ACE (tACE) 294

BBB, composed of brain endothelial cells, astrocytes, pericytes, neurons, supporting structures (microglia, oligodendrocytes), and extracellular matrix (ECM), acts as a selective barrier regulating the exchange of substances between the bloodstream and brain parenchyma while preventing the entry of harmful substances [10]

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Repeat treatment may be considered if symptoms recur, with a similar dosing schedule