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Six arachidonic acid lipoxygenase (ALOX) genes in humans (ALOX5, ALOX12, ALOX12B, ALOX15, ALOX15B and ALOXE3) have distinct expression profiles in different tissues (37)

Mice tolerated doses several times higher than the effective dose with no observable adverse effects

Cleve Clin J Med 2010;77:195-204

Moreover, angiotensin II elicited an increase in mtROS levels
