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In a 2020 case study , researchers reported a young woman treated with multiple daily doses of 1 milligram (mg) of cyanocobalamin (synthetic vitamin B12) for severe pernicious anemia (lack of red blood cells due to vitamin B12 deficiency)

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There is a study published in #ScienceDirect in August 2024 (A pilot study) concluded that B12 bioavailability reduced significantly from baseline (C) when metformin (M) was administered and this reduction was reversed when calcium was co-administered (MC) in healthy participants