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Molloy CA, Kalkwarf HJ, Manning-Courtney P, Mills JL, Hediger ML: Plasma 25(OH)D concentration in children with autism spectrum disorder

doi: 10.1523/JNEUROSCI.0242-04.2004

Other important risk factors for hyperhomocysteinemia include obesity and cigarette smoking.1,3,7 Congenital defects in the enzymes that regulate homocysteine metabolism are a primary cause of hyperhomocysteinemia

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This brings up an important hypothesis: could a high incorporation of Neu5Gc into colonic tissue ( via a Western diet high in red meat) impair Siglec-8's ability to recognize its ligands, thus blunting the brake on eosinophils