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In particular, EGCG activates the mitochondrial apoptotic pathway by downregulating SIRT1 expression to modulate the SIRT1-p53 axi [46]

[DOI] [PMC free article] [PubMed] [Google Scholar] 14.Pieters TT, van Dam MJ, Sikma MA, van Arkel A, Veldhuis WB, Verhaar MC, et al

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Milk thistle may also increase the clearance of certain medications including losartan and metronizadole (1,14)

Watanabe, F., Hashizume, E., Chan, G

It works best alongside structured nutrition, training, or another weight-management therapy
