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Loss of RNF8 significantly stabilized FSP1GFP fluorescence in cells expressing ectopic D285N FSP1GFP (Extended Data Fig

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MA: Formal analysis, Investigation, Methodology, Resources, Writing original draft, Writing review & editing

Furthermore, researchers have found that the gene expression of vasoactive intestinal peptide (VIP)-expressing interneurons is downregulated in individuals with ASD compared to healthy controls, with the most significant differential expression, suggesting potential dysfunction of VIP interneurons in people with ASD ( In addition, Reelin is an extracellular matrix glycoprotein closely related to neural development, which is involved in the regulation of neuronal migration, synaptic plasticity and neural network formation (36).Reelin affects the migration and synaptic integration of GABAergic interneurons by regulating disabled-1 (Dab1) and PI3K/AKT pathways

In addition, by integrating WES, WGS, RNA sequencing (RNA-seq), miRNA, and DNA methylation analysis, along with high-resolution mass spectrometry proteomics data, researchers successfully classified Lung Adenocarcinoma (LUAD) into four subtypes with different clinical and molecular characteristics, discovering unique mutation features associated with specific populations (Heo et al., 2021)