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Simultaneously, systematically exploring the synergistic mechanisms of multitargets will contribute to surmounting the challenge presented by the complexity of DAMP signaling networks

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As a result, the first conclusion we can obtain from these results is that more studies are necessary in order to evaluate potential combinatory treatments in order to delay or prevent AD, which, after all, is a multifactorial disease and might need to be treated through multiple targets

The cell organelle provides specific posttranslational modifications and guides the substances by means of vesicular transport to secrete them into the interstitial space (Unlu et al., 2014

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