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Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators

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Interestingly, we observed that while cisplatin decreased this ratio (by increasing STAT1 and decreasing STAT3 ), trans-tympanic administration of SB225002, not only restored this ratio but increased it to ~2-fold ( Figure 4B )

Physiological oxysterols, particularly neuron-derived 24S-OHC, support synaptic plasticity, cholesterol homeostasis and myelin maintenance through tightly regulated engagement of NMDA receptors, LXRs and glial metabolic pathways