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It has been proposed that mitochondrial dysfunction and oxidative stress contribute to the incidence and progression of neurological disorders involving Alzheimers disease

Discovery of Ubiquinone (Coenzyme Q) and an Overview of Function

The compound established multiple non-covalent interactions with the -tubulin binding pocket, including two carbon hydrogen bonds with LEU227 (2.40 ) and ARG275 (2.46 )

[No authors listed]

The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism