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All vitamin E congeners undergo phase I metabolism and are -hydroxylated at the terminal methyl group in the side chain by a CYP, in humans probably CYP4F2 ( Reference Sontag and Parker 50 , Reference Bardowell, Duan and Manor 51 )

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doi:10.1016/j.tiv.2011.03.006 Chandrasekaran K, Swaminathan K, Kumar SM, Clemens DL, Dey A (2012) Increased oxidative stress and toxicity in ADH and CYP2E1 overexpressing human hepatoma VL-17A cells exposed to high glucose

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