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Because this patient does not have the disease, the 25% chance of being affected is eliminated from the denominator

(Source 1) With age comes a gradual decline in NAD+ production and recycling

As a reminder, hypothyroidism is when the thyroid gland is not releasing enough thyroid hormone for metabolic demands

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One reason for this is that many potentially helpful drugs simply cant reach the areas of the brain that need them
2006;10:R155
