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This multi-modal strategy costs less than repeated professional-only treatments producing superior long-term outcomes versus topical-only protocols potentially producing incomplete results in moderate to severe cases

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doi: 10.3389/fphar.2025.1621030 Summary Keywords epigenetic modifications, macrophage polarization, metabolic reprogramming, pulmonary arterial hypertension, pulmonary vascular remodeling, therapeutic targets Citation Xu W, Shen Y, Wan Z and Guo J (2025) Macrophage-driven immunopathology in pulmonary arterial hypertension: from mechanisms to targeted therapies

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Additionally, both pDCs and mDCs from older women show diminished responsiveness to TLR stimuli, including TLR7 and TLR8 activation [254]

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