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In addition, phenolics exhibit their anti-inflammatory effects through the suppression of pro-inflammatory mediators and cytokines expression 57,58

These findings highlight the gutkidney axis as a central therapeutic target for TFA in DN management

USA 113 , E4338E4347 (2016)

Schwingshackl, L

These substrates are coupled by transfer enzymes to endogenous metabolites (e.g., glucuronic acid and its derivatives, sulfuric acid, acetic acid, amino acids, and the tripeptide glutathione) in reactions that often involve high-energy intermediates (Table 4-2)

Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFB and AhR and EGFR-ERK pathway