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Although it shows a protective effect against hypertension and kidney damage induced by RUPP rats when administered in late gestation, it exacerbates the preeclampsia-like phenotype when given in early gestation, predisposing to a smaller placenta and increasing proteinuria

Nat Genet 13, 189195

Staszkiewicz R, Gadysz D, Gralewski M, Garczarek M, Gadzieliski M, Grabarek BO

Studies are also underway for a spectrum of other conditions, including Phase 3 trials investigating non-alcoholic steatohepatitis (NASH), chronic kidney disease (CKD), and obstructive sleep apnea (OSA), as well as mid-to-late stage trials exploring potential benefits in neurodegenerative disorders like Parkinsons disease

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The main objective of this review was to synthesize qualitative and quantitative data from research examining the gut microbiota composition, inflammatory markers, and therapeutic outcomes of interventions targeting the microbiome in the context of ME/CFS