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Briefly, glutathione disulfide is held in the proximity of the catalytically active reducing thiol group and one thiol glutathione unit is detached in the first of the two reductive steps, leaving the enzyme in a cysteine-glutathionylated form

The studies in yeast provided the first direct evidence for ATP-dependent, low-affinity transport of GSH in any cell type (Rebbeor et al., 1998a), and demonstrated that this ATP-dependent GSH transport in yeast is mediated by Ycf1p, the yeast orthologue of mammalian MRP1 and MRP2 (Rebbeor et al., 1998b)

doi: 10.1016/S2213-2600(20)30079-5 299 YangJ.ZhengY.GouX.PuK.ChenZ.GuoQ.et al

Williams last appeared on her show on July 16, 2021

J Inorg Biochem 194:97113

He et al., 2015), as well as nasopharyngeal cancer (Quan et al., 2018)