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ALA is neurotoxic and thought to be the cause of the acute porphyria-like pathology in this TYRSN1

These include mild cognitive impairment (NCT02741804), Gulf War illness (NCT02909686), diabetic and chronic kidney disease (NCT03325322), frail elderly syndrome (NCT03675724), frailty and childhood cancer (NCT04733534), skeletal health (NCT04313634), COVID-19 (NCT04476953, NCT04771611, and NCT04537299), knee osteoarthritis (NCT04210986, NCT04815902, NCT05276895, NCT04770064, and NCT05482672), meniscus tear (NCT05505747), femoroacetabular impingement (NCT05025956), primary open-angle glaucoma (NCT04784234), carpal tunnel syndrome (NCT05416515), multimorbidity (NCT06431932), sepsis (NCT05758246), endothelial dysfunction and arterial stiffness (NCT06133634), and peripheral arterial disease (NCT06399809)

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In parallel, accumulating evidence suggests that AAS exposure may exert neurotoxic effects, contribute to cognitive impairment, and induce long-lasting behavioural and affective disturbances (91)

The outcome measures were extended to reduced thiols and vitamin E

Hashimoto Thyroiditis: Clinical and Diagnostic Criteria