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Supplementary material The Supplementary Material for this article can be found online at: Abbreviations Angptl4 Angiopoietin-Like 4 bLPL bovine LPL BSA Bovine Serum Albumin CVD cardiovascular disease CXN calnexin EL endothelial lipase ER endoplasmic reticulum fAngptl4 full-length Angptl4 FFA free fatty acids GPIHBP1 glycosylphosphatidylinositol-anchored high-density lipoproteinbinding protein 1 HDX-MS Hydrogen Deuterium Exchange Mass Spectrometry HL hepatic lipase HR heparin release HTG hypertriglyceridemia KRP Krebs Ringer Phosphate LMF1 lipase maturation factor LPL lipoprotein lipase nAngptl4 N-terminal domain Angptl4 PC proprotein convertase PHP post-heparin plasma SorLA sortilin-related receptor with type-A repeats TG triglyceride TRL TG-rich lipoproteins VLDL very-low density lipoproteins

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Consistently, oral administration of a CutC/D inhibitor markedly reduced plasma TMAO levels and rescued diet-induced platelet hyperreactivity and thrombosis without significant toxicity or increased bleeding risk (Roberts et al., 2018)

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7 Alcar, Stress, Depression & Dementia Research investigating ALCARs mechanisms of action is helping to give more insight into how and why stress can lead to depression

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and T.N

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doi: 10.1016/j.ejca.2013.09.007 173 ShoushtariANWagstaffJAsciertoPAButlerMOLaoCDMarquez-RodasIet al

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Accumulation of ketone bodies in the blood vessels induces neutrophilic inflammation (239)

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