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The structurally simplified Ang IV peptidemimetic 16 was almost as active as Ang IV as an IRAP inhibitor while 17 was five-fold and 18 and the open chain 19 were 20-fold less active (Figure 5)

Enteric Glia Enteric glia represent a large, structurally and molecularly diverse population of nonneuronal cells that are distributed in all layers and along the length of the GI tract, in close association with the ENS and nerve fibers that innervate the gut (84, 242, 267, 268)

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Long-term weight maintenance typically requires ongoing treatment or aggressive lifestyle modifications that most people find difficult to sustain

Shimizu T, Numata T, Okada Y