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The incidence of antibody formation was 44% with exenatide, 8.6% with liraglutide, 69.8% with lixisenatide, 4% with albiglutide, and 1.6% with dulaglutide [48, 103-106]
Furthermore, the use of once weekly subcutaneous tirzepatide, a dual GLP1RAs and GIP agonist, reduced the systolic blood pressure from baseline by 7.4 to 10.6 mmHg, compared to placebo [28]
Nomiyama, T
PubMed, Weidinger, Stephan, et al
The trial demonstrated that tirzepatide was non-inferior to dulaglutide for the primary MACE outcome (HR 0.92
If diarrhea occurs, switch to low-fiber foods temporarily and focus on staying hydrated
