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Because Pin1 has been implicated in dephosphorylation of tau protein, it can be hypothesized that in vivo oxidative modification of Pin1, as found in AD hippocampus, reduces Pin1 activity, leading to increased tau phosphorylation (199)

Castillo 2014)

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state that despite a paucity of supporting evidence, many experts will tolerate a few daily seizures to mitigate the risk of complications associated with profound sedation. (38117319) [#4] lift sedation to determine if seizures can be controlled off anesthetic infusions Anesthetic infusions are weaned off (while continuing maintenance antiseizure medications)