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What's Happening: NAD+ restoration begins affecting mitochondrial function

For example, Angong Niuhuang Wan inhibits the accumulation of ROS and Fe 2+ and improves mitochondrial dysfunction and BBB structural integrity by activating the PPAR/AKT/GPX4 pathway, thereby enhancing neurological function in rats with ischemic stroke and reducing cerebral infarction volume

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Vitamin B 6 is an important coenzyme required for the general metabolic maintenance of cells including the degradation of amino acids and the synthesis of many neurotransmitters including dopamine, GABA, serotonin, noradrenaline, and histamine, among others [19]

These hallmarks of aging satisfy three conditions: (i) they become apparent with advancing age, (ii) experimentally perturbing them causes poor aging (iii) therapeutically intervening upon them prevents, delays or reverses aging phenotypes