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Concurrently, TGF-1-mediated fibrous encapsulation drives joint structural remodeling and cartilage degradation ( 2.2 Pathogenesis and pathophysiology of hyperuricemia Hyperuricemia is the precursor state to gout, but its pathophysiological impact extends far beyond the joints, involving multiple systems, including cardiovascular diseases, chronic kidney disease, and metabolic disorders (Figure 2

Concurrently, microbial regulation of host tryptophan metabolism occurs through serotonin synthesis and kynurenine pathway modulation(Roager and Licht, 2018)

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Again, the Fasn mRNA levels remained unchanged (Figure 5M), reinforcing the posttranslational downregulation of FASN by GSH depletion

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5d) show high PDR at the locations of high iron concentration according to the DAB-enhanced Perls staining