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Suppressing MYC targets and PI3K-AKT-mTOR signaling creates a low-growth state

Comprehensive laboratory monitoring showed no clinically significant changes in hematology, biochemistry, or urinalysis parameters

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Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification

[5] MSM decreases exercise-induced inflammation, which may support recovery and improved performance

Therefore, this suggests that the metabolic stress induced by GLS1 knockdown can trigger autophagy as a survival mechanism