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Upon activation of a GPCR, the heterotrimeric G protein dissociates into and subunits, which then modulate the function of a diverse array of effector proteins to simultaneously influence many cellular functions (Latek et al., 2012)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 174.Pacifici R., Marchei E., Salvatore F., Guandalini L., Busard F.P., Pichini S

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This neuroprotective effect was proposed to be the result of an induction of anti-apoptotic factors such as activated kinase 1 (PAK1), protein kinase B (AKT), lim domain kinase 2 (LIMK2), mitogen-activated protein kinase, and cofilin