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doi:10.2337/dc19-2046 Giacco F, Brownlee M

The atypical enzymatic activity of nuclear LDHA catalyzes the conversion of -KB to - hydroxybutyrate (-HB), leading to -HB accumulation

Additionally, pro-inflammatory factors such as CRP, IL-6 and IL-18, which are closely associated with the incidence of CVDs, are also elevated in the plasma of women with PCOS patients ( The critical role of macrophages in the pathogenesis of CVDs in PCOS has been recently reported, with a substantial augmentation in the number of M1-macrophages in the hearts of PCOS model mice, predominantly derived from circulating monocytes ( 2.3.2 Liver The prevalence of NAFLD is higher in PCOS patients than in healthy women (34%70% vs