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Freemark, M., Driscoll, P., Maaskant, R., Petryk, A

Too much and the side effects intensify

Postmenopausal women who carried the C677T variant had a 2 to 3-fold increased risk of depression.[ref] Women with two copies of the A1298C variant were at twice the risk of major depressive disorder (MDD)

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Recently, it has been argued that oral intake of other antioxidants, including vitamin C and E, do not elevate PGC-1 in the skeletal muscle of mice and humans [29,30]