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TakechiHMawatariKHaradaNNakayaYAsakuraMAiharaMet al

conducted a placebo-controlled double-blind RCT on 180 females

Levels of KL-6 (a marker for AEC injury), ColIV1, and ColIV3 (markers for BM destruction) were significantly elevated in the serum of animals in the induced group, signifying that BLM caused AEC damage that resulted in the release of KL-6 23 and recruitment of inflammatory cells (e.g., monocytes) leading to the release of MMPs which results in further degradation of the surrounding BM and the release of collagen type IV fragments into the blood circulation 58,64

Garca-Lpez, M

Drug Des Dev Ther 10:16491661 Ding RB, Bao J, Deng CX (2017) Emerging roles of SIRT1 in fatty liver diseases

the long-term body-composition outcomes rest more on user reports than on large human trials
