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The drug concentration in the tumor reached the therapeutic threshold without harming adjacent normal cells
PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model
Column chromatography was performed on silica gel (Kieselgel 60, 70230 mesh, Merck, Darmstadt, Germany), and semi-preparative HPLC was performed using a Waters HPLC system (Waters, Milford, MA, USA) equipped with two Waters 515 pumps with a 2996 photodiode-array detector
However, excessive nitric oxide production causes inflammation and oxidative stress by interacting with molecular oxygen, producing nitrite (NO 2 - ) and other nitrogen oxide species 70
In addition, adipose tissue in the microenvironment is also capable of secreting IGF-1 to support microenvironmental remodeling (75)
Vazquez-Roque, M
