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These findings suggest that in DCM, lipotoxicity resulting from altered substrate metabolism not only causes direct lysosomal injury through membrane peroxidation, but also impairs lysosomal renewal and autophagic capacity by downregulating critical regulators such as TFEB (Trivedi et al., 2016

10.1007/s00702-019-02138-1 110 DevosD.LabreucheJ.RascolO.CorvolJ

10.3390/ijms21031135 185 TanD.-X.HardelandR.ManchesterL

It becomes much harder at enterprise scale

[DOI] [PMC free article] [PubMed] [Google Scholar] 19.Liang D., Li G., Liao X., Yu D., Wu J., Zhang M

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