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PMID: 15333481 Fikree A, Aktar R, Grahame R, Hakim AJ, Morris JK, Knowles CH, Aziz Q

This, along with a potential increase in apnoeic threshold brought on by hypoxia (which lowers the CO2 reserve even more), predisposes to central apnoea at the onset of sleep and subsequent ventilatory instability, which manifests as a hyperventilation and apnoea cycle (Hernandez & Patil, 2016)

[DOI] [PubMed] [Google Scholar] 77.Giacco A, Delli Paoli G, Senese R, Cioffi F, Silvestri E, Moreno M, et al

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