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In another set of experiments, cells were preincubated with 10 M LY294002 for 30 min at 37 C and then stimulated with bTNF- for 5 min
The literature retrieval strategy is provided in Supplementary File 1
Available: [21] S
Generally, yesbecause they work on different pathways
When two agonists bind the same receptor, the second one isn't adding a new signal it is competing for finite binding sites on a pathway that is already being stimulated
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