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In human case reports involving serotonergic agents, symptoms progress from agitation and confusion to autonomic instability (tachycardia, blood pressure fluctuations), severe hyperthermia above 40C, and in extreme cases, rhabdomyolysis

doi: 10.1016/s1530-891x(20)39448-9 61 HackettGColeNSaghirAJonesPStrangeRCRamachandranS

PLT levels significantly increased in rats treated with CHY (50, 75, and 100 mg/kg), increasing the likelihood that thrombocytopenia brought on by INH and RFM might be reversed

References Lpez-Otn, C., Blasco, M

Effects of low-pH stress on the morphology and activity of bacteria from lakes receiving acid precipitation

7 In severe cases, patients may develop acute renal failure requiring hemodialysis