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Leu244 at the 2 nd activity controller position of jr PPO1-wt was mutated to a positively charged arginine (Leu244Arg), leading to a decrease of the k cat values for mono- and diphenolic substrates by 15-fold for tyramine, 4-fold for dopamine and 11-fold for L -DOPA in comparison to jr PPO1-wt (Table 2)

10.21037/tcr-20-887 41 FengW.HanZ.ZhuR.LiuP.LiuS

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