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The risks include skewed experimental data, difficulty replicating studies, and potential toxicity or unexpected biological interactions from impurities or unlisted excipients

Sep-Oct 2021;23(5):441-449

doi: 10.3389/fnut.2019.00093 Pubmed Abstract CrossRef Google Scholar View reference in article 74 ShiptonMJThachilJ

[DOI] [PubMed] [Google Scholar] 99.Dua K., Malyla V., Singhvi G., Wadhwa R., Krishna R.V., Shukla S.D., Shastri M.D., Chellappan D.K., Maurya P.K., Satija S., et al

Evidence (CD22-targeted CAR T-cell therapy): Investigators at the NCI reported a phase I/II trial of 58 children and young adults treated with a CD22-targeted CAR T-cell approach.[207][Level of evidence C2] Of the 55 patients with ALL who were infused, 40 achieved CRs (73%)

Due to the complicated metabolites found in botanical drugs, studying the active metabolites became the mainstream of TCM research