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Instead, Vederas and coworkers synthesized and fed 13 C-labeled acyl-SNACs as precursors to the dehydrocurvularin and hypothemycin PKSs to compete with natural acyl intermediates, and used 13 C NMR of the resulting products to verify incorporation of the advanced acyl intermediates

They discovered that ES can promote a distinct form of copper-dependent cell death and initially proposed the concept of cuproptosis

The correct selection of coupling method depends on the ligand characteristics [4]

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