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Supplementation with probiotics and prebiotics can promote the dominance of beneficial bacterial populations, thereby inhibiting the conversion of dietary lecithin, L-carnitine, and choline into TMA, which is subsequently oxidized to TMAO in the liver

Additionally, PARK7 deficiency in Drosophila and human cells increases the activity of glycolytic enzymes (Solana-Manrique et al., 2022)

In line with these data, it was shown that senescent pancreatic beta cells exhibit increased mitochondrial biogenesis [99]

Essential Supplements for Bone Protection A targeted supplement regimen can make a significant difference in maintaining bone density: Calcium + Vitamin D3 Daily requirement : 1,000-1,200mg calcium and 2,000-5,000 IU vitamin D3 Best forms : Calcium citrate (more easily absorbed than calcium carbonate), vitamin D3 (cholecalciferol) Timing : Split calcium doses throughout the day for better absorption Vitamin K2 Daily requirement : 100- 200 mcg Function : Directs calcium to your bones rather than soft tissues and blood vessels Forms : MK-7 form has better bioavailability than MK-4 Magnesium Daily requirement : 320-420mg daily Forms : Magnesium glycinate or malate for better absorption and less digestive discomfort Benefits : Works synergistically with calcium and vitamin D Collagen Peptides Daily requirement : 10-15g Function : Provides the protein matrix upon which bone mineralization occurs Bonus : Also supports skin, hair, and joint health 2