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Only the functionalization with A-GSH ligands of 3-PLG-dopa or 3-PLG-ibu elevated significantly the cellular uptake indicating a lesser role in physicochemical properties like charge for these nanocarriers
Nat Neurosci 5 : 405414
It turns out that it probably isnt
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may be accompanied by inflammatory cells
Another approach uses nasal spray for maintenance phases after an initial injection loading phase
