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Findings from human trials showed that a single bout of isometric knee extension resistance exercise (40% and 110% of maximal effort) (Vega et al., 2010) elicits an increase in circulating serum IGF-1 in young adults, similar to both moderate (50% 1RM) and high-intensity (80% 1RM) resistance exercise (Tsai et al., 2014)

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