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[PMC free article: PMC6201603] [PubMed: 30374398] 15

While early and smaller trials showed promising fat-loss effects, the largest Phase IIb trial did not achieve statistical significance in humans for its primary endpoint of weight reduction, which led to the program being discontinued

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doi: 10.1016/j.phymed.2024.156115 239 ZhouYJiaZWangJHuangSYangSXiaoSet al

5.2 The Role of Glutamine Metabolism in Tumor-Associated Macrophages Macrophages in the tumor microenvironment can define the immune landscape of a tumor, depending on the cytokines that they produce

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