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Most MS studies utilize structural MRI for identifying lesions and determining if they are active based on gadolinium enhancement ( Materials and Methods Overview of Study Written informed consent, approved by the Institutional Review Board of Thomas Jefferson University, was obtained from all subjects and the study was registered on clinicaltrials.gov with the following identifier: NCT03032601

Although direct evidence of CHAC1 involvement in human neurodegeneration remains limited, its well-established role in GSH catabolism positions it mechanistically at the intersection of ferroptotic pathways

In brief, the coding sequence of the luciferase reporter gene luc2 (from Photinus pyralis ) was amplified by PCR from the pGL4.50[luc2/CMV/Hygro] vector (Promega, E1310) and flanking XhoI restriction sites were added

N., Mehrotra, R., Choudhury, Y
