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The physicochemical and colloidal properties of liposomes including their size, composition, loading efficiency, and stability are responsible for the benefits and limitations of liposomes as carriers for drugs [3]

However, research suggests that interventions that target these processes, such as medications that modulate neurotransmitter function or antioxidants that reduce oxidative stress, may be effective in reducing pain and other symptoms in people with FM 14,15,16

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When comparing based on IC50 values, while 4-amino-2-chloropyrimidine showed three times more inhibition than pyrimidine (a), 4-amino-6- chloropyrimidine (c) and 4-amino-2,6-dichloropyrimidine (d) exhibited similar levels of inhibition