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Unlike other AMPK activators, A-769662 directly activates native AMPK complex purified from rat liver in cell-free assays by mimicking both the effects of AMP on allosteric activation, as revealed by the AMPK subunit and LKB1 knockout cell lines, and inhibition of dephosphorylation of AMPK complex (225, 293)

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Triheptanoin dramatically reduces paroxysmal motor disorder in patients with GLUT1 deficiency

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Alternative expression of statin, a non proliferation specific protein, and PCNA (cyclin), a proliferation specific protein, during transition from quiescent to replicating state

An amount of 0.625 mM butyrate (Sigma) was used as an anti-inflammatory positive control