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This review assesses the clinical applicability of potential biomarkers in terms of cost, expertise required, repeatability between studies, and logistics

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Topalian SL, Sznol M, McDermott DF, Kluger HM, Carvajal RD, Sharfman WH, Brahmer JR, Lawrence DP, Atkins MB, Powderly JD, et al

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These both have to do with B12's effect on the nervous system