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An altered pH in the solvent can cause them to denature, aggregate, or simply fail to dissolve properly

9 Taken together, these exciting characteristics of the scopolamine-induced AD group make it a reliable and time-effective in vivo model to investigate the pharmacological effects of different therapeutic agents

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The review also describes evidence from preclinical and clinical studies on targeting novel non-VEGF angiogenic pathways in breast cancer and several approaches to the normalization of tumor vasculature by targeting pericytes, utilization of microRNAs and extracellular tumor-associate vesicles, using immunotherapeutic drugs, and nanotechnology