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Ketogenic diet in neurodegenerative diseases Central features of neurodegenerative diseases are neuronal oxidative stress and mitochondrial dysfunction

27, 28 Mutations in MECP2 were first reported in 1999, 29 and subsequent screening of RTT patients has shown that almost 9095% of classical RTT have pathogenic mutations

Koepsell, 2020)

MRI studies have further identified gray matter atrophy in the prefrontal cortex, medial cingulate gyrus, and hippocampus, regions that are critically involved in memory, decision-making, and emotional regulation (Thompson et al., 2004)