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Various factors may have contributed to these mixed results, including participant heterogeneity, compliance issues, and the aggressive placebo response often seen in obesity trials where lifestyle modification is encouraged

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Gordon B, Fogel L, Varma G, et al

As a result, daratumumab has shown a remarkable impact in treating lupus patients ( Mayo Clinic is currently conducting a Phase 2 clinical trial (NCT04868838) to assess the effectiveness and safety of Daratumumab in patients diagnosed with active LN

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